What does Dilantin interact with

Interacting AgentExamplesOtherCorticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin DDrugs whose level is decreased by phenytoin

What drugs should not be taken with Dilantin?

• HYDANTOINS/SELECTED ANTICOAGULANTS (VITAMIN K ANTAGONISTS)
• SELECTED ANTICONVULSANTS; BARBITURATES/CONTRACEPTIVES.
• SELECTED ANTICONVULSANTS; BARBITURATES/TELITHROMYCIN.
• PHENYTOIN/SULTHIAME.
• HYDANTOINS/FLUOROURACIL & FLUOROURACIL PRODRUGS.
• SELECTED ANTICONVULSANTS; BARBITURATES/SLT AZOLE ANTIFUNGALS.

Can you take Dilantin with other medications?

What other drugs will affect Dilantin? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can interact with phenytoin.

What can you not take with phenytoin?

may decrease the absorption of phenytoin. Do not take these products at the same time as your phenytoin dose. Separate liquid nutritional products at least 1 hour before and 1 hour after your phenytoin dose, or as directed by your doctor.

What are the most common drug drug interactions with phenytoin?

• Acetylsalicylic Acid (aspirin)
• Advair Diskus (fluticasone / salmeterol)
• Aspirin Low Strength (aspirin)
• Combivent (albuterol / ipratropium)
• Coumadin (warfarin)
• Keppra (levetiracetam)
• Lasix (furosemide)
• Lipitor (atorvastatin)

Can I take aspirin with Dilantin?

If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs.

Can you take Tylenol and Dilantin together?

Using acetaminophen together with phenytoin may alter the effects of acetaminophen and cause serious side effects that may affect your liver.

Can you mix Dilantin with milk?

You may give phenytoin with food or milk, but be consistent. Always give phenytoin with food or milk or always give it on an empty stomach. If your child is taking chewable tablets, encourage your child not to swallow them whole.

Does phenytoin interact with aspirin?

The addition of aspirin will produce no change in the free phenytoin concentration and thus no phenytoin toxicity (20 , 21) .

What are the symptoms of too much Dilantin?

• Coma.
• Confusion.
• Staggering gait or walk (early sign)
• Unsteadiness, uncoordinated movements (early sign)
• Involuntary, jerky, repeated movement of the eyeballs called nystagmus (early sign)
• Seizures.
• Tremor (uncontrollable, repeated shaking of the arms or legs)
• Sleepiness.

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What precautions would you take for a patient on phenytoin?

Check with your doctor right away if you have chest pain, dizziness, or tiredness. This medicine may cause liver damage. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin.

Is Dilantin hard on kidneys?

DILANTIN can cause a type of serious allergic reaction that may affect different parts of the body such as your liver, kidneys, blood, heart, skin or other parts of your body. These can be very serious and cause death.

Can I take Aleve with Dilantin?

No interactions were found between Aleve and Dilantin. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

What does phenytoin react with?

The most common cause of drug interactions with phenytoin is induction of the cytochrome P-450 isoenzymes CYP2C, CYP2D, and CYP3A subfamilies and UDP-glucuronosyltransferase. Metabolism of drugs that are substrates for these isoenzymes can be enhanced, thereby decreasing their serum concentrations.

How long does Dilantin stay in your system?

When taken orally, Dilantin has a 22-hour plasma half-life and peaks 4 to 12 hours after ingestion. With intravenous administration, that half-life drops to 10 to 15 hours.

What happens when Dilantin level is too high?

The NIH notes that very high levels of Dilantin may even lead to seizures, the same condition the drug is meant to control. Symptoms of Dilantin toxicity may include the following: Fast, uncontrollable eye movements or double vision (nystagmus) Dizziness, drowsiness, or confusion.

Can you take vitamin D with Dilantin?

phenytoin cholecalciferol Using phenytoin together with cholecalciferol may decrease the effects of cholecalciferol. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications.

Can I take Advil with Dilantin?

Aspirin is safe for most adults, but should be avoided by children and anyone using Depakote or Dilantin. Ibuprofen (Advil and Motrin) is another good drug for fever and pain but it can cause side effects like dizziness and difficulty walking when used in combination with Dilantin.

Does magnesium interact with Dilantin?

Aluminum hydroxide, magnesium hydroxide, and calcium may bind to phenytoin in your digestive tract, preventing your body from absorbing your phenytoin.

What drugs should not be taken together?

Specifically, drugs that slow down breathing rate, such as opioids, alcohol, antihistamines, CNS depressants, or general anesthetics, should not be taken together because these combinations increase the risk of life-threatening respiratory depression.

What medicines should not be taken together?

• Two or more drugs that share an active ingredient. You could have side effects or an overdose. …
• Blood-thinning drugs with NSAIDs. Your odds for a dangerous bleed could go up. …
• Pills with antihistamines.

Which medicines Cannot be taken together?

• Dangerous duo: Tylenol and multi-symptom cold medicines. …
• Dangerous duo: Any combo of ibuprofen, naproxen, and aspirin. …
• Dangerous duo: Antihistamines and motion-sickness medications. …
• Dangerous duo: Anti-diarrheal medicine and calcium supplements. …
• Dangerous duo: St.

Should you brush your teeth after taking phenytoin?

In some patients (usually younger patients), tenderness, swelling, or bleeding of the gums (gingival hyperplasia) may appear soon after phenytoin treatment is started. To help prevent this, brush and floss your teeth carefully and regularly and massage your gums.

Do you take phenytoin on an empty stomach?

This medicine can be taken with food or on an empty stomach. Try to take it the same way each day, since taking this with food may change the time it takes to be absorbed. Do not take antacids or medicine for diarrhea within 2 to 3 hours of taking phenytoin.

Can you take aspirin and valproate?

valproic acid aspirin You may need dose adjustments or special tests in order to safely take both medications together. Small single doses of aspirin are unlikely to cause significant effects. However, if you take aspirin over a prolonged period of time you may need your valproic acid levels checked.

Should you shake Dilantin?

Shake this medication well before each dose. Take this medication by mouth usually 2 or 3 times a day, or as directed by your doctor. This product is not recommended for use once a day. You may take it with food if stomach upset occurs.

How does phenytoin affect vitamin D?

The Mechanism for Phenytoin (Dilantin) Associated Decreases in Vitamin D. Summary: … As it relates to patients taking phenytoin, it is known that these patients have lower levels of 25-hydroxyvitamin D levels and can begin to manifest as early as 60 days after starting phenytoin.

Can you take calcium with Dilantin?

phenytoin calcium carbonate Separate the times of administration of calcium carbonate and phenytoin by at least two to three hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications.

What is a good Dilantin level?

The therapeutic range is 10-20 mcg/mL. Total phenytoin levels (mcg/mL) and typical corresponding signs and symptoms are as follows: Lower than 10 – Rare. Between 10 and 20 – Occasional mild nystagmus.

How often do Dilantin levels need to be checked?

A level can be taken 2-4 hours following an IV loading or top-up dose (12-24 hours for oral doses) and levels should then be monitored every 24 hours until control is achieved and concentration has stabilised.

Is there a difference between phenytoin and Dilantin?

Phenytoin is the generic name of a widely used antiepileptic drug (AED). In the United States, phenytoin is known by the brand names Dilantin and Phenytek (an extended-release form).